FDA's requirements for approval of new and generic drugs and biologics are among the highest standards across the globe. CARDIAC GLYCOSIDES, R01B — NASAL DECONGESTANTS FOR SYSTEMIC USE, S01GA — Sympathomimetics used as decongestants, Cardiac Stimulants Excl. While they have been used by 10% of American children in any given week, they are not recommended in Canada or the United States in children six years or younger because of lack of evidence showing effect and … The risk or severity of Tachycardia can be increased when Phenylephrine is combined with Aclidinium. Build effective decision support tools with the industry’s most comprehensive, Easily connect various identifiers back to our datasets, InChI=1S/C9H13NO2/c1-10-6-9(12)7-3-2-4-8(11)5-7/h2-5,9-12H,6H2,1H3/t9-/m0/s1, 3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol, Accelerate your drug discovery research with our ADMET & drug target dataset, phenylethanolamines, secondary amino compound (, Upper respiratory tract hypersensitivity reaction, site unspecified, Vasoconstrictor in regional analgesia therapy, Dextromethorphan hydrobromide monohydrate, S01FB — Sympathomimetics excl. Epub 2006 Feb 28. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The metabolism of Agomelatine can be increased when combined with Phenylephrine. Be careful if you drive or do anything that requires you to be alert and able to see clearly. Nucleic Acids Res. Store at room temperature away from moisture and heat. Chlorpheniramine is used to treat runny nose, sneezing, itching, and watery eyes … Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. 2007 Nov 14;573(1-3):201-5. Identification Name Prochlorperazine Accession Number DB00433 Description. 2 … Expatica is the international community’s online home away from home. Ask your doctor before taking chlorpheniramine with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures. The metabolism of Acyclovir can be increased when combined with Phenylephrine. [, Tomiyama Y, Kobayashi K, Tadachi M, Kobayashi S, Inada Y, Kobayashi M, Yamazaki Y: Expressions and mechanical functions of alpha1-adrenoceptor subtypes in hamster ureter. 1999 Feb;40(2):232-8. Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,6,8 dilate the pupil,7 and induce local vasoconstriction.1 The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s.2, Phenylephrine was granted FDA approval in 1939.7, Phenylephrine injections are indicated to treat hypotension caused by shock or anesthesia,6,8 an ophthalmic formulation is indicated to dilate pupils7 and induce vasoconstriction, an intranasal formulation is used to treat congestion, and a topical formulation is used to treat hemorrhoids.1 Off-label uses include situations that require local blood flow restriction such as the treatment of priapism.1, Phenylephrine is an alpha-1 adrenergic agonist that raises blood pressure,6,8 dilates the pupils,7 and causes local vasoconstriction.1 Ophthalmic formulations of phenylephrine act for 3-8 hours7 while intravenous solutions have an effective half life of 5 minutes and an elimination half life of 2.5 hours.3,6 Patients taking ophthalmic formulations of phenylephrine should be counselled about the risk of arrhythmia, hypertension, and rebound miosis.7 Patients taking an intravenous formulation should be counselled regarding the risk of bradycardia, allergic reactions, extravasation causing necrosis or tissue sloughing, and the concomitant use of oxytocic drugs.6,8, Phenylephrine is an alpha-1 adrenergic agonist that mediates vasoconstriction1 and mydriasis7 depending on the route and location of administration. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. 2019 Jul;29(5):99-105. doi: 10.1097/FPC.0000000000000371. Phenylephrine is a decongestant which narrows the small blood vessels providing relief from congestion or stuffiness in the nose. 2007 Jul;27(3):137-42. Phenylephrine is a decongestant which narrows the small blood vessels providing relief from congestion or stuffiness in the nose. Available for Android and iOS devices. The risk or severity of hypertension can be increased when Phenylephrine is combined with Aceclofenac. Use exactly as directed on the label, or as prescribed by your doctor. Data sources include IBM Watson Micromedex (updated 3 Mar 2021), Cerner Multum™ (updated 1 Mar 2021), ASHP (updated 3 Mar 2021) and others. U.S. Patent US6187956, issued February, 1976. Dextromethorphan was granted FDA approval before 3 December 1957. Do not take extra medicine to make up the missed dose. 2002 Jan 1;30(1):412-5. 1996 Dec;37(12):1923-31. You should not use chlorpheniramine if you are allergic to it, or if you have: a blockage in your stomach or intestines; Ask a doctor or pharmacist if it is safe for you to take chlorpheniramine if you have: a blockage in your digestive tract (stomach or intestines), a colostomy or ileostomy; asthma or COPD, cough with mucus, or cough caused by smoking, emphysema, or chronic bronchitis; high blood pressure, heart disease, coronary artery disease, or recent heart attack; pheochromocytoma (an adrenal gland tumor); or. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. [citation needed] Codral is a brand name manufactured by Johnson & Johnson and sold primarily in … Drug created on June 13, 2005 13:24 / Updated on March 04, 2021 11:38, Accelerate your drug discovery research with our fully connected ADMET dataset, With our commercial data, access important information on, Our Blackbox Warnings cover Risks, Contraindications, and Adverse Effects, Reduce medical errors & improve treatment outcomes with our adverse effects data. Avoid becoming overheated or dehydrated during exercise and in hot weather. 2006 Jun 20;79(4):331-41. FDA pregnancy category B. Chlorpheniramine is not expected to harm an unborn baby. In 2010 the use of FDA approved generics saved $158 billion, an average of $3 billion every week. The therapeutic efficacy of Phenylephrine can be decreased when used in combination with Acebutolol. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. chlorpheniramine is usually taken only for a short time until your symptoms clear up. ZELNORM (tegaserod maleate) FDA-2018-P-4549 Unichem Pharmaceuticals (USA), Inc. Terbinafine Tablets FDA-2018-P-4590 FDA-2018-P-4591 International Maple Syrup Institute Pure Maple Syrup Definition Ascend Laboratories, LLC Cannabidiol Oral Solution, 100 mg/mL FDA-2018-P-4642 Provetica Animal Health LLC Cyclosporine Capsules FDA-2018-P-4656 [. An elixir is a sweet liquid used for medical purposes, to be taken orally and intended to cure one's illness. Do not use this medicine without your doctor's advice if you are pregnant. Chlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Prochlorperazine, also known as compazine, is a piperazine phenothiazine and first-generation antipsychotic drug that is used for the treatment of severe nausea and vomiting, as well as short-term management of psychotic disorders such as … Systemic exposure to phenylephrine also leads to agonism of alpha-1 adrenergic receptors, raising systolic and diastolic pressure as well as peripheral vascular resistance.6,8 Increased blood pressure stimulates the vagus nerve, causing reflex bradycardia.6,8, Phenylephrine is 38% orally bioavailable.3 Clinically significant systemic absorption of ophthalmic formulations is possible, especially at higher strengths and when the cornea is damaged.6, The volume of distribution of phenylephrine is 340L.6,8, Data regarding the protein binding of phenylephrine in serum is not readily available.6,7,8, Phenylephrine is mainly metabolized by monoamine oxidase A, monoamine oxidase B, and SULT1A3.4,5,6,8 The major metabolite is the inactive meta-hydroxymandelic acid, followed by sulfate conjugates.5,6,8 Phenylephrine can also be metabolized to phenylephrine glucuronide.5, Hover over products below to view reaction partners, 86% of a dose of phenylephrine is recovered in the urine3 with 16% as the unmetabolized drug, 57% as the inactive meta-hydroxymendelic acid, and 8% as inactive sulfate conjugates.6,8, Intravenous phenylephrine has an effective half life of 5 minutes and an elimination half life of 2.5 hours.3,6,8, Phenylephrine has an average clearance of 2100mL/min.6,8, Patients experiencing and overdose may present with headache, hypertension, reflex bradycardia, tingling limbs, cardiac arrhythmias, and a feeling of fullness in the head.6,7,8 Overdose may be treated by supportive care and discontinuing phenylephrine, chronotropic medications, and vasodilators.1 Subcutaneous phentolamine may be used to treat tissue extravasation.1,7. The metabolism of Acenocoumarol can be increased when combined with Phenylephrine. chlorpheniramine may cause blurred vision or impair your thinking or reactions. Chericof Syrup is a combination of three medicines: Phenylephrine, Chlorpheniramine Maleate and Dextromethorphan Hydrobromide, which relieves dry cough. If you believe you are experiencing an interaction, contact a healthcare provider immediately. 1944 Oct;6(4):214-20. doi: 10.1136/hrt.6.4.214. Academia.edu is a platform for academics to share research papers. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. 1993 Nov-Dec;13(6 Pt 2):116S-128S; discussion 143S-146S. The risk or severity of hypertension can be increased when Phenylephrine is combined with Acemetacin. Coricidin, Coricidin D, or Coricidin HBP, is the brand name of a combination of dextromethorphan and chlorpheniramine maleate (an antihistamine). 2015 Sep;35(9):547-58. doi: 10.1007/s40261-015-0311-9. [, Kanfer I, Dowse R, Vuma V: Pharmacokinetics of oral decongestants. Generic Name: chlorpheniramine (KLOR fen IR a meen)Brand Name: Aller-Chlor, Allergy Relief, C.P.M., Chlo-Amine, Chlor-Mal, ChlorTan, Chlor-Trimeton, Ed ChlorPed, Ed-Chlor Ped Jr, Ed-Chlortan, PediaTan, Triaminic Allergy, Wal-finate, ...show all 31 brand namesChlor-Phenit, Ridramin, Allergy Relief (Chlorpheniramine), Chlor-Al Rel, Chlor-Phen, Chlorphen, Efidac-24 Chlorpheniramine, Chlor-Trimeton Allergy SR, QDALL AR, AHist (obsolete), P-Tann, Chlorpheniramine (Allergy), Pediox-S, Ed Chlor-Tan, TanaHist-PD, Pharbechlor, Allergy Time, Chlorphen SRDosage Forms: oral liquid (1 mg/5 mL; 2 mg/mL); oral suspension, extended release (8 mg/5 mL); oral syrup (2 mg/5 mL); oral tablet (4 mg); oral tablet, chewable (2 mg); oral tablet, extended release (12 mg; 8 mg; tannate 8 mg). GlaxoSmithKline Consumer Healthcare Holdings (US) LLC, Assured Maximum Strength Nasal Decongestant, Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc, Pfizer Canada Inc., Consumer Healthcare Division, Berkley and Jensen Nasal Decongestant PE Non-Drowsy Maximum Strength, Ophthalmic; Oral; Respiratory (inhalation); Topical, 7 Select Night Time Severe Cold Cough and Flu, 7 Select Night Time severe cold, cough and flu, (−)-m-hydroxy-α-(methylaminomethyl)benzyl alcohol, Prescott F: CLINICAL EVALUATION OF THE PRESSOR ACTIVITY OF METHEDRINE, NEO-SYNEPHRINE, PAREDRINE, AND PHOLEDRINE. Br Heart J. Ask a doctor or pharmacist before using any other cold, cough, allergy, or sleep medicine. Chlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. You should not use chlorpheniramine if you have narrow-angle glaucoma, a blockage in your stomach or intestines, an enlarged prostate, if you are unable to urinate, or if you are having an asthma attack. You may report side effects to FDA at 1-800-FDA-1088. Generic Drug Facts and Statistics. J Nucl Med. Franz Dietrich Klinger, Lienhard Wolter, Wolfgang Dietrich, "Method for preparing of L-phenylephrine hydrochloride." [, Hein, L. (2004). Life Sci. Medically reviewed by Drugs.com on April 13, 2020. In 2010 the use of FDA approved generics saved $158 billion, an average of $3 billion every week. Chlorpheniramine is used to treat runny nose, sneezing, itching, and watery eyes caused by allergies, the common cold, or the flu. [, Konstandi M, Kostakis D, Harkitis P, Johnson EO, Marselos M, Adamidis K, Lang MA: Benzo(alpha)pyrene-induced up-regulation of CYP1A2 gene expression: role of adrenoceptor-linked signaling pathways. Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. [, Bairam AF, Rasool MI, Alherz FA, Abunnaja MS, El Daibani AA, Gohal SA, Alatwi ES, Kurogi K, Liu MC: Impact of SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of phenylephrine and salbutamol by human SULT1A3 allozymes. Breaking the pill may cause too much of the drug to be released at one time. Taking certain products together can cause you to get too much of a certain drug. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Cardiac Glycosides, Compounds used in a research, industrial, or household setting, Cytochrome P-450 CYP1A2 Inducers (strength unknown), Sympathomimetics Excl. alpha-Adrenergic system. The metabolism of Albendazole can be increased when combined with Phenylephrine. Auton Autacoid Pharmacol. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Ask a doctor or pharmacist before using chlorpheniramine if you are also using any other drugs, including prescription and over-the-counter medicines, vitamins, and herbal products. Select one or more newsletters to continue. 27-30). Prochlorperazine, also known as compazine, is a piperazine phenothiazine and first-generation antipsychotic drug that is used for the treatment of severe nausea and vomiting, as well as short-term management of psychotic disorders such as generalized non-psychotic anxiety and schizophrenia. Phenylephrine is a decongestant which narrows the small blood vessels providing relief from congestion or stuffiness in the nose. A must-read for English-speaking expatriates and internationals across Europe, Expatica provides a tailored local news service and essential information on living, working, and moving to your country of choice. In Encyclopedic reference of molecular pharmacology (pp. J Nucl Med. Since this medicine is taken when needed, you may not be on a dosing schedule. Some medicines can cause unwanted or dangerous effects when used together. Drug Quality: Postmarket Sampling and Testing. [, Gelotte CK, Zimmerman BA: Pharmacokinetics, safety, and cardiovascular tolerability of phenylephrine HCl 10, 20, and 30 mg after a single oral administration in healthy volunteers. Antihistamines may also slow breast milk production. The U.S. FDA requires generic drugs have the same high quality, strength, purity and stability as brand-name drugs. Expatica is the international community’s online home away from home. Chlorpheniramine may also be used for purposes not listed in this medication guide. Do not allow the liquid form of this medicine to freeze. [, Raffel DM, Corbett JR, del Rosario RB, Gildersleeve DL, Chiao PC, Schwaiger M, Wieland DM: Clinical evaluation of carbon-11-phenylephrine: MAO-sensitive marker of cardiac sympathetic neurons. Berlin: Springer. Pyrilamine maleate Sodium borate Trolamine salicylate Turpentine oil Zinc oxide Zirconium oxide (vii) Poison ivy, poison oak, and poison sumac drug products. Academia.edu is a platform for academics to share research papers. When used as a pharmaceutical preparation, an elixir contains at least one active ingredient designed to be taken orally.