painful swelling, inflammation) the treatment with Ciprofloxacin should be discontinued and alternative treatment should be considered. If taken on an empty stomach, the active substance is absorbed more rapidly. However, the concurrent administration of dairy products or mineral-fortified drinks alone (e.g. Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity. Therefore, concomitant use of corticosteroids should be avoided.At the first sign of tendinitis (e.g. In diabetic patients, careful monitoring of blood glucose is recommended.

Treatment of infections due to certain bacteria (e.g.

In clinical studies, it was demonstrated that concomitant use of duloxetine with strong inhibitors of the CYP450 1A2 isozyme such as fluvoxamine, may result in an increase of AUC and CIt was shown in a clinical study that concomitant use of ropinirole with ciprofloxacin, a moderate inhibitor of the CYP450 1A2 isozyme, results in an increase of CIt was demonstrated in healthy subjects that concomitant use of lidocaine containing medicinal products with ciprofloxacin, a moderate inhibitor of CYP450 1A2 isozyme, reduces clearance of intravenous lidocaine by 22%. Daily dose in mg. Total duration of treatment (potentially including initial parenteral treatment with ciprofloxacin) Infections of the lower respiratory tract . infection is due to its public health effect by diminishing transmission through decreasing the duration of faecal carriage (from approximately 4 weeks to 3 days) with effective treatment. A 500 mg oral dose given every 12 hours has been shown to produce an area under the serum concentration-time curve (AUC) equivalent to that produced by an intravenous infusion of 400 mg ciprofloxacin given over 60 minutes every 12 hours. Ciprofloxacin is not recommended for the treatment of streptococcal infections due to inadequate efficacyGonococcal uretritis, cervicitis, epididymo-orchitis and pelvic inflammatory diseases may be caused by fluoroquinolone-resistant Therefore, ciprofloxacin should be administered for the treatment of gonococcal uretritis or cervicitis only if ciprofloxacin-resistant For epididymo-orchitis and pelvic inflammatory diseases, empirical ciprofloxacin should only be considered in combination with another appropriate antibacterial agent (e.g. “BAYER” on the reverse side.Ciproxin 500 mg film-coated tablets are indicated for the treatment of the following infections (see sections 4.4 and 5.1). This is all the more to be taken into account as regards the increasing resistance level of There are limited data on the efficacy of ciprofloxacin in the treatment of post-surgical intra-abdominal infections. • Pelvic inflammatory disease including cases due to susceptible Neisseria gonorrhoeae

Cases of sensory or sensorimotor polyneuropathy resulting in paraesthesia, hypaesthesia, dysesthesia, or weakness have been reported in patients receiving quinolones and fluoroquinolones. There may be a particular risk of selecting for ciprofloxacin-resistant bacteria during extended durations of treatment and when treating nosocomial infections and/or infections caused by Ciprofloxacin inhibits CYP1A2 and thus may cause increased serum concentration of concomitantly administered substances metabolised by this enzyme (e.g.

• Inhalation anthrax (post-exposure prophylaxis and curative treatment)Ciprofloxacin may also be used to treat severe infections in children and adolescents when this is considered to be necessary.Treatment should be initiated only by physicians who are experienced in the treatment of cystic fibrosis and/or severe infections in children and adolescents (see sections 4.4 and 5.1).The dosage is determined by the indication, the severity and the site of the infection, the susceptibility to ciprofloxacin of the causative organism(s), the renal function of the patient and, in children and adolescents the body weight.The duration of treatment depends on the severity of the illness and on the clinical and bacteriological course.Treatment of infections due to certain bacteria (e.g.

Co-administration of ciprofloxacin may increase blood levels of zolpidem; concurrent use is not recommended.The data that are available on administration of ciprofloxacin to pregnant women indicates no malformative or foeto/neonatal toxicity of ciprofloxacin. Although lidocaine treatment was well tolerated, a possible interaction with ciprofloxacin associated with side effects may occur upon concomitant administration.Following concomitant administration of 250 mg ciprofloxacin with clozapine for 7 days, serum concentrations of clozapine and N-desmethylclozapine were increased by 29% and 31%, respectively. • Epididymo-orchitis including cases due to susceptible Neisseria gonorrhoeae theophylline, clozapine, olanzapine, ropinirole, tizanidine, duloxetine, agomelatine). Co-administration of ciprofloxacin and tizanidine is contra-indicated.The concomitant use of ciprofloxacin with methotrexate is not recommended (see section 4.5).Ciprofloxacin, like other fluoroquinolones, should be used with caution in patients receiving drugs known to prolong QT interval (e.g.

Very rare cases of prolonged (continuing months or years), disabling and potentially irreversible serious adverse drug reactions affecting different, sometimes multiple, body systems (musculoskeletal, nervous, psychiatric and senses) have been reported in patients receiving quinolones and fluoroquinolones irrespective of their age and pre-existing risk factors. glibenclamide) or with insulin. • Prophylaxis of invasive infections due to Neisseria meningitides The restriction does not apply to antacids belonging to the class of H2 receptor blockers.Dietary calcium as part of a meal does not significantly affect absorption.

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